Effects of ketamine and pentobarbitone on acetylcholine release from the rat frontal cortex in vivo
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چکیده
منابع مشابه
Effects of ketamine and pentobarbitone on acetylcholine release from the rat frontal cortex in vivo.
We have studied the effects of ketamine and pentobarbitone on acetylcholine (ACh) release from the rat frontal cortex using microdialysis. Ketamine 25, 50 and 100 mg kg-1 increased ACh release from the frontal cortex to 286%, 253% and 381% of basal release, respectively. In contrast, pentobarbitone 10, 20 and 40 mg kg-1 caused 73%, 78% and 96% inhibition of basal levels, respectively. The resul...
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Using microdialysis, we examined the effects of ketamine and pentobarbitone on acetylcholine (ACh) release from the rat hippocampus and striatum. Ketamine 25 and 50 mg kg-1 increased ACh release from the hippocampus to 295% and 353% of basal release, respectively, but not from the striatum. SCH 23390 1 mumol litre-1, a D1 antagonist, significantly inhibited the facilitatory effect of ketamine 5...
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ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 1997
ISSN: 0007-0912
DOI: 10.1093/bja/79.1.128